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Non-hydroxy-sphingosine

We provide MS-based lipid analysis of NS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of NS

Structure. Non-hydroxy-fatty acid [N] sphingosine [S] ceramides (CER[NS], or NS) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Non-hydroxy-sphingosines are mainly associated with human skin where they fulfill structural and signaling purposes. NS ceramides contribute to epidermal barrier function to protect against the environment and prevent trans-epidermal water loss. Skin ceramide profile aberrations can lead or contribute to skin conditions. An increase of NS ceramides is associated with psoriasis, a decrease is linked to dry skin. Further, a Nordic diet decreases NS levels in liver but increases brain levels.

Related research

Moisturizer Research
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
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GENERAL STRUCTURE
NS

General molecular structure of non-hydroxy-sphingosine.

NS lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH

REPORTED AS
NS 18:1;2/30:0;0

An example for the molecular structure of non-hydroxy-sphingosine, specifically NS 18:1;2/30:0;0.

GENERAL STRUCTURE
NS

General molecular structure of non-hydroxy-sphingosine.

REPORTED AS
NS 18:1;2/27:0;0

An example for the molecular structure of non-hydroxy-sphingosine, specifically NS 18:1;2/27:0;0.

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