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Non-hydroxy-sphingosine
We provide MS-based lipid analysis of NS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.
Details
About the structure and biological function of NS
Structure. Non-hydroxy-fatty acid [N] sphingosine [S] ceramides (CER[NS], or NS) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
NS lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum .
Function. Non-hydroxy-sphingosines are mainly associated with human skin where they fulfill structural and signaling purposes. NS ceramides contribute to epidermal barrier function to protect against the environment and prevent trans-epidermal water loss. Skin ceramide profile aberrations can lead or contribute to skin conditions. An increase of NS ceramides is associated with psoriasis, a decrease is linked to dry skin. Further, a Nordic diet decreases NS levels in liver but increases brain levels.
GENERAL STRUCTURENS
NS lipidomics analysis with
Structural details subspecies level Variants identified > 250 Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 3-6 weeks Lipidomics data pmol & mol% Figures included
1 Skin includes:
REPORTED ASNS 18:1;2/30:0;0
GENERAL STRUCTURENS
REPORTED ASNS 18:1;2/27:0;0
About Lipotype
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
