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Non-hydroxy-sphingosine

We provide MS-based lipid analysis of NS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.
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Details

About the structure and biological function of NS

Structure. Non-hydroxy-sphingosines (CER[NS], or NS) are a type of sphingosines, a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Non-hydroxy-sphingosines are mainly associated with human skin where they fulfill structural and signaling purposes. NS ceramides contribute to epidermal barrier function to protect against the environment and prevent trans-epidermal water loss. Skin ceramide profile aberrations can lead or contribute to skin conditions. An increase of NS ceramides is associated with psoriasis, a decrease is linked to dry skin. Further, a Nordic diet decreases NS levels in liver but increases brain levels.

Related research

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Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
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GENERAL STRUCTURE
NS

General molecular structure of non-hydroxy-sphingosine.

NS lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

All lipid classes

TAG DAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS Cer CL Chol CE PC O- PE O- LPC O- LPE O- SM HexCer DiHexCer Gb3 Gb4 GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Sulf Erg EE CDP-DAG IPC MIPC M(IP)2C NdS NS NP NH AdS AS AP AH EOdS EOS EOP EOH

REPORTED AS
NS 18:1;2/30:0;0

An example for the molecular structure of non-hydroxy-sphingosine, specifically NS 18:1;2/30:0;0.

GENERAL STRUCTURE
NS

General molecular structure of non-hydroxy-sphingosine.

REPORTED AS
NS 18:1;2/27:0;0

An example for the molecular structure of non-hydroxy-sphingosine, specifically NS 18:1;2/27:0;0.

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