About the structure and biological function of NS
Structure. Non-hydroxy-sphingosines (CER[NS], or NS) are a type of sphingosines, a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
NS lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum.
Function. Non-hydroxy-sphingosines are mainly associated with human skin where they fulfill structural and signaling purposes. NS ceramides contribute to epidermal barrier function to protect against the environment and prevent trans-epidermal water loss. Skin ceramide profile aberrations can lead or contribute to skin conditions. An increase of NS ceramides is associated with psoriasis, a decrease is linked to dry skin. Further, a Nordic diet decreases NS levels in liver but increases brain levels.
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
NS lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 250|
|Method||mass spectrometry (untargeted)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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