About the structure and biological function of NdS
Structure. Non-hydroxy-dihydro-sphingosines (CER[NDS], or NdS) are a type of sphinganines, a subclass of ceramides. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
NdS lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum.
Function. Non-hydroxy-dihydrosphingosines are mostly important to human skin where they serve structural and signaling roles. NdS ceramides are involved in the formation of the epidermal barrier to protect against the environment and prevent trans-epidermal water loss. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Reduced levels of NdS ceramides are linked to psoriasis. Further, a fish-rich diet decreases NdS lipids in the liver but elevates them in the brain.
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
NdS lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 250|
|Method||mass spectrometry (untargeted)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!