About the structure and biological function of LPC
Structure. Lyso-phosphatidyl-cholines (lysolecithin, LysoPtdCho, LysoPC, or LPC) are a type of glycerophosphocholines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphocholine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPC lipids are mainly found in animal blood plasma. On a subcellular level, they are enriched in lipoprotein particles.
Function. Lyso-phosphatidyl-cholines are potent signaling molecules and they have many functions related to inflammation and the immune system. They are suggested an important factor for neurodegeneration such as cognitive decline and dementia, and promote demyelination of neurons. Impaired levels of LPCs are also linked to cardiovascular disease and cancers. They have some functions in cell signaling. Further, LPC lipids have beneficial effects by activating macrophages.
LPC lipidomics analysis with
|Structural details||species level|
|Variants identified||> 100|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
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