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GT2 Ganglioside

We provide MS-based lipid analysis of GT2 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GT2

Structure. GT2 ganglioside lipids (GT2) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of six sugar molecules. Three of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the function of GT2 gangliosides in vertebrates but modified GT2 lipids have been associated with tumors. This represents an attractive target for immunotherapeutic approaches using specific GT2 antibodies. They also serve as the direct precursors of the more complex GT1 gangliosides. Further, GT2 gangliosides have been shown to interact with the tetanus toxin facilitating entry of the toxin into the cell.

GENERAL STRUCTURE
GT2

General molecular structure of the ganglioside GT2.

GT2 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified < 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GT2 34:1;2

An example for the molecular structure of ganglioside GT2, specifically GT2 34:1;2.

GENERAL STRUCTURE
GT2

General molecular structure of the ganglioside GT2.

REPORTED AS
GT2 42:1;2

An example for the molecular structure of ganglioside GT2, specifically GT2 42:1;2.

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