About the structure and biological function of GT2
Structure. GT2 ganglioside lipids (GT2) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of six sugar molecules. Three of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.
GT2 gangliosides are found in vertebrate cells, especially cells of the nervous system. On a subcellular level, they are enriched in the cell membrane and in lipid rafts.
Function. Little is known about the function of GT2 gangliosides in vertebrates but modified GT2 lipids have been associated with tumors. This represents an attractive target for immunotherapeutic approaches using specific GT2 antibodies. They also serve as the direct precursors of the more complex GT1 gangliosides. Further, GT2 gangliosides have been shown to interact with the tetanus toxin facilitating entry of the toxin into the cell.
GT2 lipidomics analysis with
|Structural details||species level|
|Variants identified||< 10|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf
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