About the structure and biological function of GT2
Structure. GT2 ganglioside lipids (GT2) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a tri-sialic oligosaccharide unit made of six sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
GT2 gangliosides are found in vertebrate cells, especially cells of the nervous system. On a subcellular level, they are enriched in the cell membrane and in lipid rafts.
Function. Little is known about the function of GT2 gangliosides in vertebrates but modified GT2 lipids have been associated with tumors. This represents an attractive target for immunotherapeutic approaches using specific GT2 antibodies. They also serve as the direct precursors of the more complex GT1 gangliosides. Further, GT2 gangliosides have been shown to interact with the tetanus toxin facilitating entry of the toxin into the cell.
GT2 lipidomics analysis with
|Structural details||species level|
|Variants identified||< 10|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf
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