About the structure and biological function of GT1
Structure. GT1 ganglioside lipids (GT1) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a tri-sialic oligosaccharide unit made of seven sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
GT1 gangliosides are found in vertebrate cells, especially cells of the nervous system. On a subcellular level, they are enriched in the cell membrane and in lipid rafts.
Function. GT1 gangliosides belong to the major gangliosides of the mammal brain. Within the cell membrane of the axons of neurons, GT1 lipids bind to the myelin-associated glycoprotein, a membrane protein of the innermost myelin membrane wrap. This interaction maintains and regulates axon-myelin stability. Further, GT1 gangliosides act as the receptor for the tetanus toxin and further neurotoxins.
GT1 lipidomics analysis with
|Structural details||species level|
|Variants identified||> 10|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf
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