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GT1 Ganglioside

We provide MS-based lipid analysis of GT1 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GT1

Structure. GT1 ganglioside lipids (GT1) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of seven sugar molecules. Three of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GT1 gangliosides belong to the major gangliosides of the mammal brain. Within the cell membrane of the axons of neurons, GT1 lipids bind to the myelin-associated glycoprotein, a membrane protein of the innermost myelin membrane wrap. This interaction maintains and regulates axon-myelin stability. Further, GT1 gangliosides act as the receptor for the tetanus toxin and further neurotoxins.

GENERAL STRUCTURE
GT1

General molecular structure of the ganglioside GT1.

GT1 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GT1 38:1;2

An example for the molecular structure of ganglioside GT1, specifically GT1 38:1;2.

GENERAL STRUCTURE
GT1

General molecular structure of the ganglioside GT1.

REPORTED AS
GT1 40:1;2

An example for the molecular structure of ganglioside GT1, specifically GT1 40:1;2.

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