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GQ1 Ganglioside

We provide MS-based lipid analysis of GQ1 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GQ1

Structure. GQ1 ganglioside lipids (GQ1) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of eight sugar molecules. Four of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GQ1 gangliosides belong to the major gangliosides of the mammal brain. In Miller Fisher syndrome, a rare autoimmune nerve disease that is considered to be a variant of Guillain-Barré syndrome, patients have a unique antibody against GQ1 lipids. Patients experience paralysis of ocular muscles, absence of reflexes, and lack of voluntary coordination of muscle movements. Further, GQ1 levels are reduced in Alzheimer’s models and GQ1 gangliosides have been shown to interact with the cholera toxin.

GENERAL STRUCTURE
GQ1

General molecular structure of the ganglioside GQ1.

GQ1 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GQ1 38:1;2

An example for the molecular structure of ganglioside GQ1, specifically GQ1 38:1;2.

GENERAL STRUCTURE
GQ1

General molecular structure of the ganglioside GQ1.

REPORTED AS
GQ1 34:1;2

An example for the molecular structure of ganglioside GQ1, specifically GQ1 34:1;2.

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