About the structure and biological function of GM3
Structure. GM3 ganglioside lipids (GM3) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a mono-sialic oligosaccharide unit made of three sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
GM3 gangliosides are found in vertebrates, especially in nervous tissue and the intestine. On a subcellular level, they are enriched in the cell membrane and in lipid rafts.
Function. GM3 lipids are the simplest gangliosides chemically and serve as precursors of more complex gangliosides but also fulfill a structural role themselves. In the cell membrane, they associate with each other and other lipids into lipid rafts and caveolae. The concentration of GM3 in caveolae affects the activity of receptors involved in the regulation of glucose uptake. They also are critical for cochlear hair cells and essential for hearing. Further, modified GM3 lipids are found in many cancers, including melanomas and stage II breast cancers.
GM3 lipidomics analysis with
|Structural details||species level|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!