About the structure and biological function of GM1
Structure. GM1 ganglioside lipids (monosialotetrahexosylgangliosides, GM1) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of five sugar molecules. One of them is a sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.
GM1 gangliosides are found in vertebrate cells, especially cells of the nervous system. On a subcellular level, they are enriched in the cell membrane and in lipid rafts.
Function. GM1 gangliosides promote differentiation of various neuronal cells. They have protective effects on the neural system by supporting neural stem cell survival and proliferation, regeneration of axons, and inhibiting neurodegeneration through autophagy, cellular “self-eating”. In lipid rafts, GM1 lipids serve a key role in several signaling systems. However, GM1 lipids also act as specific receptors for the cholera toxin. GM1 accumulation leads to GM1 gangliosidosis, a lysosomal storage disease causing generalized symptoms including mental retardation.
GM1 lipidomics analysis with
|Structural details||species level|
|Variants identified||> 25|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!