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GM1 Ganglioside

We provide MS-based lipid analysis of GM1 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GM1

Structure. GM1 ganglioside lipids (monosialotetrahexosylgangliosides, GM1) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of five sugar molecules. One of them is a sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GM1 gangliosides promote differentiation of various neuronal cells. They have protective effects on the neural system by supporting neural stem cell survival and proliferation, regeneration of axons, and inhibiting neurodegeneration through autophagy, cellular “self-eating”. In lipid rafts, GM1 lipids serve a key role in several signaling systems. However, GM1 lipids also act as specific receptors for the cholera toxin. GM1  accumulation leads to GM1 gangliosidosis, a lysosomal storage disease  causing generalized symptoms including  mental retardation.

GENERAL STRUCTURE
GM1

General molecular structure of the ganglioside GM1.

GM1 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GM1 34:1;2

An example for the molecular structure of ganglioside GM1, specifically GM1 34:1;2.

GENERAL STRUCTURE
GM1

General molecular structure of the ganglioside GM1.

REPORTED AS
GM1 36:1;2

An example for the molecular structure of ganglioside GM1, specifically GM1 36:1;2.

About Lipotype

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