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GD3 Ganglioside

We provide MS-based lipid analysis of GD3 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GD3

Structure. GD3 ganglioside lipids (GD3) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of four sugar molecules. Two of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GD3 gangliosides are fundamental in neurogenesis. They bind to the EGF receptor resulting in the activation of a signaling cascade promoting cell proliferation. This is essential for stem cell self-renewal in the brain. GD3 lipids are critical for apoptosis and autophagy, programmed cell death and cellular “self-eating”. They also serve as precursors of more complex gangliosides. Further, GD3 levels are elevated in melanomas and neuroblastomas, and they are the main gangliosides in early human breast milk.

GENERAL STRUCTURE
GD3

General molecular structure of the ganglioside GD3.

GD3 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GD3 34:1;2

An example for the molecular structure of ganglioside GD3, specifically GD3 34:1;2.

GENERAL STRUCTURE
GD3

General molecular structure of the ganglioside GD3.

REPORTED AS
GD3 36:1;2

An example for the molecular structure of ganglioside GD3, specifically GD3 36:1;2.

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