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GD2 Ganglioside

We provide MS-based lipid analysis of GD2 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GD2

Structure. GD2 ganglioside lipids (GD2) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of five sugar molecules. Two of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GD2 gangliosides have been linked to many cancers. While only present in trace amounts in normal tissues, GD2 lipids are found at much higher concentrations in cancer cells, especially in melanomas and neuroblastomas. They are considered tumor-associated antigens and the enzyme GD2 synthase is investigated as potential drug target. In neuroblastoma, a GD2 antibody has been approved for treatment in combination with other drugs but they also serve as circulating biomarkers.

GENERAL STRUCTURE
GD2

General molecular structure of the ganglioside GD2.

GD2 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GD2 36:1;2

An example for the molecular structure of ganglioside GD2, specifically GD2 36:1;2.

GENERAL STRUCTURE
GD2

General molecular structure of the ganglioside GD2.

REPORTED AS
GD2 40:1;2

An example for the molecular structure of ganglioside GD2, specifically GD2 40:1;2.

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