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GD1 Ganglioside

We provide MS-based lipid analysis of GD1 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GD1

Structure. GD1 ganglioside lipids (GD1) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a di-sialic oligosaccharide unit made of six sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. GD1 gangliosides, at times considered a reserve pool for GM1 lipids, belong to the major gangliosides of the mammal brain. During embryogenesis and the postnatal period the amount of GD1 lipids in the human central nervous system increases up to 15-fold. Further, some GD1 lipids have anti-inflammatory properties by inhibiting the effects of bacterial lipopolysaccharides and preventing cytokine activation. In mice, GD1 gangliosides are important for oocyte maturation and fertilization.

GENERAL STRUCTURE
GD1

General molecular structure of the ganglioside GD1.

GD1 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GD1 34:1;2

An example for the molecular structure of ganglioside GD1, specifically GD1 34:1;2.

GENERAL STRUCTURE
GD1

General molecular structure of the ganglioside GD1.

REPORTED AS
GD1 38:1;2

An example for the molecular structure of ganglioside GD1, specifically GD1 38:1;2.

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