Home   Lipidomics Analysis   Gb4 Analysis 

Gb4 Globoside

We provide MS-based lipid analysis of Gb4 globosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of Gb4

Structure. Gb4 globoside lipids (globo-tetraosylceramides, cytolipin R, or Gb4) are a type of globosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a neutral oligosaccharide unit made of four sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Gb4 globosides are the main glycolipids found in the cell membrane of human erythrocytes. There, they are important for cellular interactions including blood-type determinants, factors which determine the suitability of donor blood for a patient. Each of the three distinct blood group antigens (A, B, and 0) is defined by a variation of the oligosaccharide unit. Gb4 lipids also act as the receptor for the parvovirus B19, which infects rapidly dividing cells of the intestines and the bone marrow causing (fifth disease) in children.

GENERAL STRUCTURE
Gb4

General molecular structure of the globoside Gb4.

Gb4 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
Gb4 36:1;2

An example for the molecular structure of globoside Gb4, specifically Gb4 36:1;2.

GENERAL STRUCTURE
Gb4

General molecular structure of the globoside Gb4.

REPORTED AS
Gb4 44:1;2

An example for the molecular structure of globoside Gb4, specifically Gb4 44:1;2.

About Lipotype

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!