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Ether-linked phosphatidyl-ethanolamine

We provide MS-based lipid analysis of PE O- phospholipids in a variety of sample types and deliver results in as little as two weeks.
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Details

About the structure and biological function of PE O-

Structure. Ether-linked phosphatidyl-ethanolamine (plasmanyl-phosphatidyl-ethanolamines, alkyl-phosphatidyl-ethanolamines, or PE O-) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphoethanolamine molecule. One of the fatty acids is bound to the glycerol backbone via an ether bond. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Ether-linked phosphatidyl-ethanolamines contain high amounts of arachidonic acid required for the biosynthesis of eicosanoids, bioactive lipids with a great role in inflammation. Levels of PE O- lipids are reduced in the blood of patients with multiple sclerosis. That said, elevated levels have been found in cancers, especially in aggressive forms. Further, PE O- lipids are important membrane constituents of neutrophils, the most abundant type of white blood cells in humans.

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GENERAL STRUCTURE
PE O-

General molecular structure of ether-linked phosphatidylethanolamine.

PE O- lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM

All lipid classes

TAG DAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS Cer CL Chol CE PC O- PE O- LPC O- LPE O- SM HexCer DiHexCer Gb3 Gb4 GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Sulf Erg EE CDP-DAG IPC MIPC M(IP)2C NdS NS NP NH AdS AS AP AH EOdS EOS EOP EOH

REPORTED AS
PE O- 16:0;0/22:4;0

An example for the molecular structure of ether-linked phosphatidylethanolamine, specifically PE O- 16:0;0/22:4;0.

GENERAL STRUCTURE
PE O-

General molecular structure of ether-linked phosphatidylethanolamine.

REPORTED AS
PE O- 18:0;0/22:6;0

An example for the molecular structure of ether-linked phosphatidylethanolamine, specifically PE O- 18:0;0/22:6;0.

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