Home   Lipidomics Analysis   PE O- Analysis 

Ether-linked phosphatidyl-ethanolamine

We provide MS-based lipid analysis of PE O- phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of PE O-

Structure. Ether-linked phosphatidyl-ethanolamine (plasmanyl-phosphatidyl-ethanolamines, alkyl-phosphatidyl-ethanolamines, or PE O-) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid, a fatty alcohol and a phosphoethanolamine molecule. One of the fatty acids is bound to the glycerol backbone via an ether bond. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Ether-linked phosphatidyl-ethanolamines contain high amounts of arachidonic acid required for the biosynthesis of eicosanoids, bioactive lipids with a great role in inflammation. Levels of PE O- lipids are reduced in the blood of patients with multiple sclerosis. That said, elevated levels have been found in cancers, especially in aggressive forms. Further, PE O- lipids are important membrane constituents of neutrophils, the most abundant type of white blood cells in humans.

Related research

Biomarkers for Multiple Sclerosis
Diagnosing multiple sclerosis is difficult. Lipid markers can support diagnosis and treatment of the neuroinflammatory disease.
Read more

GENERAL STRUCTURE
PE O-

General molecular structure of ether-linked phosphatidylethanolamine.

PE O- lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, CL, PC O-, PE O-, LPC O-, LPE O-, Cer, HexCer

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, PC O-, PE O-, Chol, CE, Cer, SM

REPORTED AS
PE O- 16:0;0/22:4;0

An example for the molecular structure of ether-linked phosphatidylethanolamine, specifically PE O- 16:0;0/22:4;0.

GENERAL STRUCTURE
PE O-

General molecular structure of ether-linked phosphatidylethanolamine.

REPORTED AS
PE O- 18:0;0/22:6;0

An example for the molecular structure of ether-linked phosphatidylethanolamine, specifically PE O- 18:0;0/22:6;0.

About Lipotype

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!