About the structure and biological function of LPE O-
Structure. Ether-linked lyso-phosphatidyl-ethanolamines (LPE O-) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid via an ether bond and a phosphoethanolamine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPE O- lipids are found in animals and microbes. On a subcellular level, they may be enriched in the cell membrane and lipid droplets.
Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-ethanolamines, but they are precursors to ether-linked phosphatidyl-ethanolamines. In the pigmented layer of the human retina that nourishes retinal visual cells, LPE O- lipids are linked to the formation of bisretinoids. Bisretinoids are a family of fluorescent molecules that form in photoreceptor cells and contribute to some retinal diseases, thus LPE O- lipids are suggested to play a role in retinal health.
LPE O- lipidomics analysis with
|Structural details||species level|
|Variants identified||> 25|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer
2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer
LPE O- 18:1;0
LPE O- 16:0;0
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