About the structure and biological function of DAG
Structure. Diacylglycerols (diglycerides, DAG, or DG) are a type of glycerolipids. Their structure consists of a glycerol backbone linked to two fatty acids. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Diacylglycerols are found in all organisms and each cell type, though at low concentrations. On a subcellular level, they are enriched in biological membranes.
Function. Diacylglycerols have different biological functions, of which many depend on the position of the two fatty acids at the glycerol backbone. Thus, diacylglycerols serve as key intermediates in the synthesis of glycerolipids such as glycerophospholipids and triacylglycerols. They can also function in cellular signaling, and their physical properties influence cell membrane biophysics. They are important immunomodulators. Further, diacylglycerols accumulate in many organs in obesity and can be an important factor in cancer.
Multiomics in Type 1 Diabetes
Combined transcriptomic, proteomic, lipidomic, & metabolomic analyses can characterize the molecular basis of diabetes.
DAG lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 500|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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