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Cholesteryl esters

We provide MS-based lipid analysis of CE sterol lipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of CE

Structure. Cholesteryl esters (cholesterol esters, or CE) are a type of sterol lipids. Their structure consists of cholesterol where an ester bond is formed between the hydroxyl group of the steroid structure and a fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Cholesteryl esters function as a transport form of cholesterol in blood plasma and in cells in lipid droplets. They serve as  storage containers  to  buffer excess cholesterol. They also serve as pool for cholesterol, for example for hormone synthesis in the adrenal glands, but also for free fatty acids. Cholesteryl esters accumulate in fatty lesions of atherosclerotic plaques. Further, cholesterol is inefficiently converted to cholesteryl esters in the blood of cardiovascular disease patients.

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GENERAL STRUCTURE
CE

General molecular structure of cholesteryl esters.

CE lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Basic includes:
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, PC O-, PE O-, Chol, CE, Cer, SM

3Skin includes:
TAG, DAG, Chol, CE, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH

REPORTED AS
CE 16:4;0

An example for the molecular structure of cholesteryl esters, specifically CE 16:4;0.

GENERAL STRUCTURE
CE

General molecular structure of cholesteryl esters.

REPORTED AS
CE 16:2;0

An example for the molecular structure of cholesteryl esters, specifically CE 16:2;0.

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