About the structure and biological function of CE
Structure. Cholesteryl esters (cholesterol esters, or CE) are a type of sterol lipids. Their structure consists of cholesterol where an ester bond is formed between the hydroxyl group of the steroid structure and a fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Cholesteryl esters are mainly found in animal blood plasma and cells. On a subcellular level, they are enriched in cellular lipid droplets.
Function. Cholesteryl esters function as a transport form of cholesterol in blood plasma and in cells in lipid droplets. They serve as storage containers to buffer excess cholesterol. They also serve as pool for cholesterol, for example for hormone synthesis in the adrenal glands, but also for free fatty acids. Cholesteryl esters accumulate in fatty lesions of atherosclerotic plaques. Further, cholesterol is inefficiently converted to cholesteryl esters in the blood of cardiovascular disease patients.
Multiomics in Type 1 Diabetes
Combined transcriptomic, proteomic, lipidomic, & metabolomic analyses can characterize the molecular basis of diabetes.
CE lipidomics analysis with
|Structural details||species level|
|Variants identified||> 50|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, PC O-, PE O-, Chol, CE, Cer, SM
TAG, DAG, Chol, CE, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH
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