About the structure and biological function of Chol
Structure. Cholesterol (Chol) is a type of sterol lipid. Its structure consists of four linked hydrocarbon rings, the steroid structure. A hydrocarbon tail is linked to one end of the steroid, a hydroxyl group linked to the other end. It contains no fatty acids.
Cholesterol is the major sterol lipid in animals and can be found in cells and body fluids like blood. On a subcellular level, it is enriched in the cell membrane and in lipid rafts.
Function. Cholesterol has a vital function in animals. It is an essential component of cell membranes and lipid rafts. It is a precursor of steroid hormones and other metabolites such as vitamin D or bile acids. Cholesterol also is important for cell signaling, transport processes, and regulation of gene readout, and an abundant constituent of the water permeability barrier in skin and of myelin in the brain. Further, excess cholesterol is linked to cardiovascular disease.
Neurons & Glia Cells
The brain of mammals is the second-most lipid-rich organ. Lipid analysis of neural cells helps understand its complex structure.
Chol lipidomics analysis with
|Structural details||class level|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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