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Ceramide

We provide MS-based lipid analysis of Cer sphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of Cer

Structure. Ceramides (Cer) are a type of sphingolipids. Their structure consists of a long-chain base which is linked to a fatty acid via an amide bond. The long-chain base and the fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Ceramides are essential intermediates in the biosynthesis of all complex sphingolipids. Except for skin, ceramides are rapidly converted and present at trace amounts only, yet they serve important biological roles. They can form ceramide-rich lipid rafts within the cell membrane, and have a vital function in cellular signaling related to apoptosis, cell differentiation, and proliferation. Further, ceramides are linked to metabolic diseases, cancer, neurodegeneration, and cardiovascular disease.

Related research

Multiomics in CVD Research
Genes and lipids have both been linked to cardiovascular disease, but their interrelationship had not been disclosed yet.
Read more

GENERAL STRUCTURE
Cer

General molecular structure of ceramides.

Cer lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM

REPORTED AS
Cer 44:1;2

An example for the molecular structure of ceramides, specifically Cer 44:1;2.

GENERAL STRUCTURE
Cer

General molecular structure of ceramides.

REPORTED AS
Cer 34:0;4

An example for the molecular structure of ceramides, specifically Cer 34:0;4.

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