About the structure and biological function of Cer
Structure. Ceramides (Cer) are a type of sphingolipids. Their structure consists of a long-chain base which contains a fatty acid. The long-chain base is linked to a further fatty acid via an amide bond. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Ceramides are found in all organisms and each cell type but are elevated in skin tissue. On a subcellular level, they are enriched in cell membranes and in lipid rafts.
Function. Ceramides are essential intermediates in the biosynthesis of all complex sphingolipids. Except for skin, ceramides are rapidly converted and present at trace amounts only, yet they serve important biological roles. They can form ceramide-rich lipid rafts within the cell membrane, and have a vital function in cellular signaling related to apoptosis, cell differentiation, and proliferation. Further, ceramides are linked to metabolic diseases, cancer, neurodegeneration, and cardiovascular disease.
Multiomics in CVD Research
Genes and lipids have both been linked to cardiovascular disease, but their interrelationship had not been disclosed yet.
Cer lipidomics analysis with
|Structural details||species level|
|Variants identified||> 100|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
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