Home   Lipidomics Analysis   CL Analysis 

Cardiolipin

We provide MS-based lipid analysis of CL phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of CL

Structure. Cardiolipins (Ptd2Gro, or CL) are a type of glycerophospholipids. Their structure consists of two diacylglycerophosphates linked to each other via a third glycerol backbone. In total, cardiolipins contain four fatty acids. They can be of variable length, hydroxylated, and contain double bonds.

Function. Cardiolipins are tied to the synthesis of ATP, cellular energy. They are a vital component of cellular membranes whose function is to generate an electrochemical potential, such as mitochondrial membranes. There, they interact with many membrane proteins regulating and controlling their functions. They are also involved in apoptosis and mitophagy, programmed cell death and mitochondrial degradation. Further, cardiolipin aberrations are linked to Barth syndrome, cancer, diabetes, and Parkinson’s disease.

GENERAL STRUCTURE
CL

General molecular structure of cardiolipin.

CL lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

REPORTED AS
CL 76:5;0

An example for the molecular structure of cardiolipin, specifically CL 76:5;0.

GENERAL STRUCTURE
CL

General molecular structure of cardiolipin.

REPORTED AS
CL 69:4;0

An example for the molecular structure of cardiolipin, specifically CL 69:4;0.

About Lipotype

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!