About the structure and biological function of AS
Structure. Alpha-hydroxy-sphingosines (CER[AS], or AS) are a type of sphingosines, a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
AS lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum.
Function. Alpha-hydroxy-sphingosines are mostly important for skin health where they serve structural and signaling roles. AS ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide imbalances can lead or contribute to the development of skin conditions. AS levels are reduced in psoriasis and dry skin. Further, AS ceramides are increased in Albino African skin.
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
AS lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 100|
|Method||mass spectrometry (untargeted)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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