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Alpha-hydroxy-sphingosine

We provide MS-based lipid analysis of AS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of AS

Structure. Alpha-hydroxy-fatty acid [A] sphingosine [S] ceramides (CER[AS], or AS) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Alpha-hydroxy-sphingosines are mostly important for skin health where they serve structural and signaling roles. AS ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide imbalances can lead or contribute to the development of skin conditions. AS levels are reduced in psoriasis and dry skin. Further, AS ceramides are increased in Albino African skin.

Related research

Moisturizer Research
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
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GENERAL STRUCTURE
AS

General molecular structure of alpha-hydroxy-sphingosines.

AS lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 100
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH

REPORTED AS
AS 16:1;2/24:0;1

An example for the molecular structure of alpha-hydroxy-sphingosines, specifically AS 16:1;2/24:0;1.

GENERAL STRUCTURE
AS

General molecular structure of alpha-hydroxy-sphingosines.

REPORTED AS
AS 18:1;2/30:0;1

An example for the molecular structure of alpha-hydroxy-sphingosines, specifically AS 18:1;2/30:0;1.

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