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Alpha-hydroxy-dihydro-sphingosine

We provide MS-based lipid analysis of AdS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of AdS

Structure. Alpha-hydroxy-fatty acid [A] dihydro-sphingosine [dS] ceramides (CER[AdS], or AdS) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological functions of alpha-hydroxy-dihydrosphingosines are mainly associated with human skin where they serve structural and signaling roles. AdS ceramides contribute to epidermal barrier function to protect against the environment and prevent trans-epidermal water loss. They are critical to barrier homeostasis. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. Further, AdS ceramides are decreased in Albino African skin.

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GENERAL STRUCTURE
AdS

General molecular structure of alpha-hydroxy-dihydrosphingosines.

AdS lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH

REPORTED AS
AdS 18:0;2/16:0;1

An example for the molecular structure of alpha-hydroxy-dihydrosphingosines, specifically AdS 18:0;2/16:0;1.

GENERAL STRUCTURE
AdS

General molecular structure of alpha-hydroxy-dihydrosphingosines.

REPORTED AS
AdS 18:0;2/22:0;1

An example for the molecular structure of alpha-hydroxy-dihydrosphingosines, specifically AdS 18:0;2/22:0;1.

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