About the structure and biological function of AH
Structure. Alpha-hydroxy-6-hydroxy-sphingosines (CER[AH], or AH) are a type of sphingosines, a subclass of ceramides. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
AH lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum.
Function. The biological roles of alpha-hydroxy-6-hydroxy-sphingosines are tightly linked to skin health where they fulfill structural and signaling purposes. AH ceramides are involved in the formation of the epidermal barrier to protect against the environment and prevent trans-epidermal water loss. They are critical for barrier homeostasis. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Further, AH ceramides are increased in Albino African skin.
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
AH lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 250|
|Method||mass spectrometry (untargeted)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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