Ceramides are integral lipids within the sphingolipid family, crucial for cellular function and health. They consist of a sphingoid base and fatty acyl chain, with variations in fatty acyls defining different ceramide types, influencing their biological function.
Ceramides are key intermediates in the synthesis of complex sphingolipids such as gangliosides. While ceramides are found in animals, plants, fungi, and bacteria, they are especially abundant in the skin, where they form a significant portion of the lipid matrix of the outermost layer.
In addition to their biosynthetic role, ceramides function as second messengers in cellular signaling, regulating membrane dynamics and lipid raft properties.
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