Trisialo­ganglioside

We provide MS-based lipid analysis of GT gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group

About the structure and biological function of GT

Structure. Trisialogangliosides (GT) belong to the group of gangliosides within the sphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide. Three of the sugar molecules are sialic acids. The total number of sugar molecules is part of the name of GT subclasses: GT1 contains seven sugars, GT2 six, and GT3 five. The ceramide backbone of trisialogangliosides contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. The biological role of trisialogangliosides is mostly associated with the neural system. Within the cell membrane of the axons of neurons, GT1 gangliosides bind to the myelin-associated glycoprotein. This interaction maintains and regulates axon-myelin stability. Little is known about the function of GT2 gangliosides and GT3 gangliosides. But modified GT2 gangliosides have been associated with tumors, and GT3 gangliosides are elevated in the retina where they are believed to play a specific role in the structure and function of the tissue.

GT lipidomics analysis with
Lipotype

Structural detailsspecies level
Noted subclassesGT1, GT2, GT3
Variants identified > 25
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
GT

An example for the molecular structure of ganglioside GT1, specifically GT1 38:1;2.

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!