Monosialo­ganglioside

We provide MS-based lipid analysis of GM gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group

About the structure and biological function of GM

Structure. Monosialogangliosides (GM) belong to the group of gangliosides within the sphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide. One of the sugar molecules is a sialic acid. The total number of sugar molecules is part of the name of GM subclasses: GM1 contains five sugars, GM2 four, GM3 three, and GM4 two. The ceramide backbone of monosialogangliosides contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. The biological function of monosialogangliosides is mainly related to the neural system. GM1 gangliosides promote differentiation of neuronal cells, support neural stem cell proliferation, and inhibit neurodegeneration. GM4 gangliosides are a major part of myelin, the insulating layer that forms around the axons of neurons. The simplest gangliosides, GM3 gangliosides, are precursors to more complex gangliosides, and GM2 gangliosides are important components of mammal cell membranes. Accumulation of GMs leads a variety of diseases of which many impact cognitive capacity.

GM lipidomics analysis with
Lipotype

Structural detailsspecies level
Noted subclassesGM1, GM2, GM3, GM4
Variants identified > 100
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
GM

An example for the molecular structure of ganglioside GM1, specifically GM1 36:1;2.

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