Omega-hydroxy­ceramide

We provide MS-based lipid analysis of EOCer skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of EOCer

Structure. Omega-hydroxyceramides (EOCer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, contain hydroxyl groups, and encompass multiple double bonds.

Function. The biological function of omega-hydroxyceramides mostly revolves around skin health, where they serve mainly structural roles. EOCer ceramides are critical to the formation of the lamellar phase of the epidermal barrier which prevents trans-epidermal water loss but also protects from the environment. Aberrations of skin ceramide levels can contribute or lead to skin conditions. In general, reduced levels of omega-hydroxyceramides are linked to dry skin and psoriasis.

EOCer lipidomics analysis with
Lipotype

Structural detailsspecies level
Noted subclassesEOdS, EOS, EOP, EOH
Variants identified > 50
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
EOCer

An example for the molecular structure of omega-hydroxy-sphingosines, specifically EOS 65:3;2.

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