About the structure and biological function of EOCer
Structure. Omega-hydroxyceramides (EOCer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, contain hydroxyl groups, and encompass multiple double bonds.
Function. The biological function of omega-hydroxyceramides mostly revolves around skin health, where they serve mainly structural roles. EOCer ceramides are critical to the formation of the lamellar phase of the epidermal barrier which prevents trans-epidermal water loss but also protects from the environment. Aberrations of skin ceramide levels can contribute or lead to skin conditions. In general, reduced levels of omega-hydroxyceramides are linked to dry skin and psoriasis.
EOCer lipidomics analysis with
|Structural details||species level|
|Noted subclasses||EOdS, EOS, EOP, EOH|
|Variants identified||> 50|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
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