About the structure and biological function of NCer
Structure. Non-hydroxyceramides (NCer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base and a fatty acid. The fatty acid is a non-hydroxy fatty acid, and can be of variable length, contain hydroxyl groups, and encompass multiple double bonds.
Function. Non-hydroxyceramides are mostly important to human skin where they serve structural and signaling roles. NCer are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Abberations in non-hydroxyceramide levels are associated with psoriasis.
NCer lipidomics analysis with
|Structural details||subspecies level|
|Noted subclasses||NdS, NS, NP, NH|
|Variants identified||> 500|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
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