Non-hydroxy­ceramide

We provide MS-based lipid analysis of NCer skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of NCer

Structure. Non-hydroxyceramides (NCer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base and a fatty acid. The fatty acid is a non-hydroxy fatty acid, and can be of variable length, contain hydroxyl groups, and encompass multiple double bonds.

Function. Non-hydroxyceramides are mostly important to human skin where they serve structural and signaling roles. NCer are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Abberations in non-hydroxyceramide levels are associated with psoriasis.

NCer lipidomics analysis with
Lipotype

Structural detailssubspecies level
Noted subclassesNdS, NS, NP, NH
Variants identified > 500
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
NCer

An example for the molecular structure of non-hydroxy-dihydrosphingosine, specifically NdS 16:0;2/23:0;0.

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!