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Alpha-hydroxyceramide
We provide MS-based lipid analysis of ACer skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.
About the structure and biological function of ACer
Structure. Alpha-hydroxyceramides (ACer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base and a fatty acid. The fatty acid is an α-hydroxy fatty acid, and can be of variable length, contain hydroxyl groups, and encompass multiple double bonds.
Function. Alpha-hydroxyceramides are tightly linked to skin health where they fulfill structural and signaling purposes. ACer ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. They are critical for barrier homeostasis. Imbalanced skin ceramides can contribute or lead to the development of skin conditions.
ACer lipidomics analysis with
Structural details subspecies level Noted subclasses AdS, AS, AP, AH Variants identified > 500 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 3-6 weeks Lipidomics data pmol & mol% Figures included
EXAMPLE STRUCTUREACer
ABOUT LIPOTYPE
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
