About the structure and biological function of ACer
Structure. Alpha-hydroxyceramides (ACer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base and a fatty acid. The fatty acid is an α-hydroxy fatty acid, and can be of variable length, contain hydroxyl groups, and encompass multiple double bonds.
Function. Alpha-hydroxyceramides are tightly linked to skin health where they fulfill structural and signaling purposes. ACer ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. They are critical for barrier homeostasis. Imbalanced skin ceramides can contribute or lead to the development of skin conditions.
ACer lipidomics analysis with
|Structural details||subspecies level|
|Noted subclasses||AdS, AS, AP, AH|
|Variants identified||> 500|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
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