Alpha-hydroxy­ceramide

We provide MS-based lipid analysis of ACer skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of ACer

Structure. Alpha-hydroxyceramides (ACer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base and a fatty acid. The fatty acid is an α-hydroxy fatty acid, and can be of variable length, contain hydroxyl groups, and encompass multiple double bonds.

Function. Alpha-hydroxyceramides are tightly linked to skin health where they fulfill structural and signaling purposes. ACer ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. They are critical for barrier homeostasis. Imbalanced skin ceramides can contribute or lead to the development of skin conditions.

ACer lipidomics analysis with
Lipotype

Structural detailssubspecies level
Noted subclassesAdS, AS, AP, AH
Variants identified > 500
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
ACer

An example for the molecular structure of alpha-hydroxy-phytosphingosines, specifically AP 20:0;3/26:0;1.

ABOUT LIPOTYPE

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