About the structure and biological function of PG
Structure. Phosphatidylglycerols (PtdGro, GPGro, or PG) are a type of glycerophosphoglycerols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphoglycerol molecule. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Phosphatidylglycerols are found in all organisms and each cell type but elevated in bacteria. On a subcellular level, they are enriched in the cell membrane.
Function. Phosphatidylglycerols are key intermediates in the biosynthesis of many lipids but especially of cardiolipin. They are essential for the development of normal membranes of chloroplasts and mitochondria in higher plants. In bacteria, phosphatidylglycerols are important for optimal functioning of the bacterial machinery and play a role in protein folding and binding. Further, phosphatidylglycerols have a role in the regulation of the innate immune response in the lungs.
PG lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 500|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM
2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer
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