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Omega-hydroxy-dihydro-sphingosine

We provide MS-based lipid analysis of EOdS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of EOdS

Structure. Omega-hydroxy-fatty acid [EO] dihydro-sphingosine [dS] ceramides (CER[EOdS], or EOdS) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological function of omega-hydroxy-dihydrosphingosines mostly revolves around skin health where they serve mainly structural roles. EOdS ceramides are critical to the formation of the lamellar phase of the epidermal barrier which prevents trans-epidermal water loss but also protects from the environment. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. In general, reduced levels of omega-hydroxy ceramides are linked to dry skin and psoriasis.

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GENERAL STRUCTURE
EOdS

General molecular structure of omega-hydroxy-dihydrosphingosines.

EOdS lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH

REPORTED AS
EOdS 66:2;2

An example for the molecular structure of omega-hydroxy-dihydrosphingosines, specifically EOdS 66:2;2.

GENERAL STRUCTURE
EOdS

General molecular structure of omega-hydroxy-dihydrosphingosines.

REPORTED AS
EOdS 70:2;2

An example for the molecular structure of omega-hydroxy-dihydrosphingosines, specifically EOdS 70:2;2.

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