About the structure and biological function of EOdS
Structure. Omega-hydroxy-dihydro-sphingosines (CER[EOdS], or EOdS) are a type of acylceramides, a subclass of ceramides. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
EOdS lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum.
Function. The biological function of omega-hydroxy-dihydrosphingosines mostly revolves around skin health where they serve mainly structural roles. EOdS ceramides are critical to the formation of the lamellar phase of the epidermal barrier which prevents trans-epidermal water loss but also protects from the environment. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. In general, reduced levels of omega-hydroxy ceramides are linked to dry skin and psoriasis.
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
EOdS lipidomics analysis with
|Structural details||species level|
|Variants identified||> 10|
|Method||mass spectrometry (untargeted)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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