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Non-hydroxy-phyto-sphingosine

We provide MS-based lipid analysis of NP skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of NP

Structure. Non-hydroxy-fatty acid [N] phytosphingosine [P] ceramides (CER[NP], or NP) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The function of non-hydroxy-phytosphingosines is tightly linked to skin health where they serve structural and signaling roles. NP ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Increased NP levels are associated with psoriasis. Further, NP ceramides are decreased in Albino African skin.

Related research

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Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
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GENERAL STRUCTURE
NP

General molecular structure of non-hydroxy-phytosphingosine.

NP lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

REPORTED AS
NP 18:0;3/30:0;0

An example for the molecular structure of non-hydroxy-phytosphingosine, specifically NP 18:0;3/30:0;0.

GENERAL STRUCTURE
NP

General molecular structure of non-hydroxy-phytosphingosine.

REPORTED AS
NP 18:0;3/26:0;0

An example for the molecular structure of non-hydroxy-phytosphingosine, specifically NP 18:0;3/26:0;0.

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