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Non-hydroxy-6-hydroxy-sphingosine

We provide MS-based lipid analysis of NH skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of NH

Structure. Non-hydroxy-6-hydroxy-sphingosines (CER[NH], or NH) are a type of sphingosines, a subclass of ceramides. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological role of non-hydroxy-6-hydroxy-sphingosines mainly revolves around skin health where they serve structural and signaling roles. NH ceramides contribute to epidermal barrier function which protects against environmental factors and prevents trans-epidermal water loss. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. Further, NH ceramides are increased during winter months in healthy skin.

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GENERAL STRUCTURE
NH

General molecular structure of non-hydroxy-6-hydroxy-sphingosine.

NH lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

REPORTED AS
NH 18:1;3/21:0;0

An example for the molecular structure of non-hydroxy-6-hydroxy-sphingosine, specifically NH 18:1;3/21:0;0.

GENERAL STRUCTURE
NH

General molecular structure of non-hydroxy-6-hydroxy-sphingosine.

REPORTED AS
NH 19:1;3/27:0;0

An example for the molecular structure of non-hydroxy-6-hydroxy-sphingosine, specifically NH 19:1;3/27:0;0.

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