About the structure and biological function of NH
Structure. Non-hydroxy-fatty acid [N] 6-hydroxy-sphingosine [H] ceramides (CER[NH], or NH) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
NH lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum.
Function. The biological role of non-hydroxy-6-hydroxy-sphingosines mainly revolves around skin health where they serve structural and signaling roles. NH ceramides contribute to epidermal barrier function which protects against environmental factors and prevents trans-epidermal water loss. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. Further, NH ceramides are increased during winter months in healthy skin.
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
NH lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 250|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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