About the structure and biological function of LPI
Structure. Lyso-phosphatidyl-inositols (LysoPtdIns, LysoPI, or LPI) are a type of glycerophosphoinositols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoinositol molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPI lipids are mainly found in eukaryotic cells. On a subcellular level, they are enriched in biological membranes.
Function. Lyso-phosphatidyl-inositols are intermediates in the remodeling of phosphatidylinositols, such as the release of arachidonic acid for eicosanoid biosynthesis. Yet, LPI lipids possess signaling functions on their own. They interact with receptors and stimulate the release of hormones from the pancreas for the regulation of glucose uptake. LPI levels are elevated in highly proliferative cancer cells and serve as biomarkers for poor prognosis in cancer patients. Further, LPIs together with other lysophospholids, are linked to a number of metabolic diseases such as obesity.
LPI lipidomics analysis with
|Structural details||species level|
|Variants identified||> 50|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer
2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!