About the structure and biological function of LPI
Structure. Lyso-phosphatidyl-inositols (LysoPtdIns, LysoPI, or LPI) are a type of glycerophosphoinositols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoinositol molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPI lipids are mainly found in eukaryotic cells. On a subcellular level, they are enriched in biological membranes.
Function. Lyso-phosphatidyl-inositols are intermediates in the remodeling of phosphatidylinositols, such as the release of arachidonic acid for eicosanoid biosynthesis. Yet, LPI lipids possess signaling functions on their own. They interact with receptors and stimulate the release of hormones from the pancreas for the regulation of glucose uptake. LPI levels are elevated in highly proliferative cancer cells and serve as biomarkers for poor prognosis in cancer patients. Further, LPIs together with other lysophospholids, are linked to a number of metabolic diseases such as obesity.
Cardiac Lipid Metabolism
Heart failure changes lipid metabolism in cardiac tissue of mice. The altered lipid profile can be confirmed in human plasma.
LPI lipidomics analysis with
|Structural details||species level|
|Variants identified||> 50|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, CL, PC O-, PE O-, LPC O-, LPE O-, Cer, HexCer
2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer
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