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Lyso-phosphatidyl-inositol

We provide MS-based lipid analysis of LPI phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of LPI

Structure. Lyso-phosphatidyl-inositols (LysoPtdIns, LysoPI, or LPI) are a type of glycerophosphoinositols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoinositol molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Lyso-phosphatidyl-inositols are intermediates in the remodeling of phosphatidylinositols, such as the release of arachidonic acid for eicosanoid biosynthesis. Yet, LPI lipids possess signaling functions on their own. They interact with receptors and stimulate the release of hormones from the pancreas for the regulation of glucose uptake. LPI levels are elevated in highly proliferative cancer cells and serve as biomarkers for poor prognosis in cancer patients. Further, LPIs together with other lysophospholids, are linked to a number of metabolic diseases such as obesity.

Related research

Cardiac Lipid Metabolism
Heart failure changes lipid metabolism in cardiac tissue of mice. The altered lipid profile can be confirmed in human plasma.
Read more

GENERAL STRUCTURE
LPI

General molecular structure of lyso-phosphatidylinositol.

LPI lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, CL, PC O-, PE O-, LPC O-, LPE O-, Cer, HexCer

2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer

REPORTED AS
LPI 18:2;0

An example for the molecular structure of lyso-phosphatidylinositol, specifically LPI 18:2;0.

GENERAL STRUCTURE
LPI

General molecular structure of lyso-phosphatidylinositol.

REPORTED AS
LPI 14:0;0

An example for the molecular structure of lyso-phosphatidylinositol, specifically LPI 14:0;0.

About Lipotype

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