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Lyso-phosphatidyl-glycerol

We provide MS-based lipid analysis of LPG phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of LPG

Structure. Lyso-phosphatidyl-glycerols (LysoPtdGro, LysoPG, or LPG) are a type of glycerophosphoglycerols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoglycerol molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the function of lyso-phosphatidyl-glycerols in animals. Elevated LPG levels have been detected in acute coronary syndrome and they may be linked to cardiovascular diseases. In bacteria, LPGs are the lipid backbone elements of lipopolysaccharides, structural components of the bacterial capsule which are important virulence factors for many pathogens. Further, LPG lipids serve as precursors for phosphatidylglycerols.

Related research

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Breast cancer phospholipid metabolism is a powerful target for new therapies, especially against triple-negative breast cancer.
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GENERAL STRUCTURE
LPG

General molecular structure of lyso-phosphatidylglycerol.

LPG lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

REPORTED AS
LPG 20:2;0

An example for the molecular structure of lyso-phosphatidylglycerol, specifically LPG 20:2;0.

GENERAL STRUCTURE
LPG

General molecular structure of lyso-phosphatidylglycerol.

REPORTED AS
LPG 16:1;0

An example for the molecular structure of lyso-phosphatidylglycerol, specifically LPG 16:1;0.

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