About the structure and biological function of LPG
Structure. Lyso-phosphatidyl-glycerols (LysoPtdGro, LysoPG, or LPG) are a type of glycerophosphoglycerols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoglycerol molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPG lipids are found in all organisms. On a subcellular level, they are enriched in the cell membrane.
Function. Little is known about the function of lyso-phosphatidyl-glycerols in animals. Elevated LPG levels have been detected in acute coronary syndrome and they may be linked to cardiovascular diseases. In bacteria, LPGs are the lipid backbone elements of lipopolysaccharides, structural components of the bacterial capsule which are important virulence factors for many pathogens. Further, LPG lipids serve as precursors for phosphatidylglycerols.
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GENERAL STRUCTURE LPG
LPG lipidomics analysis with Lipotype
Structural details
species level
Variants identified
> 25
Method
mass spectrometry
Device
Q Exactive Orbitrap (280.000 Res)
Quantification
yes
Delivery time
2-6 weeks
Lipidomics data
pmol & mol%
Figures
included
1Cells Extended includes: LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer
