About the structure and biological function of LPG
Structure. Lyso-phosphatidyl-glycerols (LysoPtdGro, LysoPG, or LPG) are a type of glycerophosphoglycerols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoglycerol molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPG lipids are found in all organisms. On a subcellular level, they are enriched in the cell membrane.
Function. Little is known about the function of lyso-phosphatidyl-glycerols in animals. Elevated LPG levels have been detected in acute coronary syndrome and they may be linked to cardiovascular diseases. In bacteria, LPGs are the lipid backbone elements of lipopolysaccharides, structural components of the bacterial capsule which are important virulence factors for many pathogens. Further, LPG lipids serve as precursors for phosphatidylglycerols.
Breast Cancer & Lipid Metabolism
Breast cancer phospholipid metabolism is a powerful target for new therapies, especially against triple-negative breast cancer.
LPG lipidomics analysis with
|Structural details||species level|
|Variants identified||> 25|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, CL, PC O-, PE O-, LPC O-, LPE O-, Cer, HexCer
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