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Lyso-phosphatidyl-ethanolamine

We provide MS-based lipid analysis of LPE phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of LPE

Structure. Lyso-phosphatidyl-ethanolamines (lysocephalins, LysoPtdEtn, LysoPE, or LPE) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoethanolamine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Lyso-phosphatidyl-ethanolamines are involved in cellular processes such as differentiation and migration of certain neuronal cells, but also of various cancer cells. In plants, LPEs function as inhibitors for a key enzyme in membrane lipid degradation, thus retarding senescence of leaves, flowers, and fruits. They are used commercially to stimulate ripening and extend shelf-life of fruit, and increase vase life of cut flowers. Further, LPE lipids serve as precursors for phosphatidyl-ethanolamines.

Related research

Breast Cancer & Lipid Metabolism
Breast cancer phospholipid metabolism is a powerful target for new therapies, especially against triple-negative breast cancer.
Read more

GENERAL STRUCTURE
LPE

General molecular structure of lyso-phosphatidylethanolamine.

LPE lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM

REPORTED AS
LPE 18:0;0

An example for the molecular structure of lyso-phosphatidylethanolamine, specifically LPE 18:0;0.

GENERAL STRUCTURE
LPE

General molecular structure of lyso-phosphatidylethanolamine.

REPORTED AS
LPE 22:5;0

An example for the molecular structure of lyso-phosphatidylethanolamine, specifically LPE 22:5;0.

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