About the structure and biological function of LPE
Structure. Lyso-phosphatidyl-ethanolamines (lysocephalins, LysoPtdEtn, LysoPE, or LPE) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoethanolamine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPE lipids are found in all organisms. On a subcellular level, they are enriched in animal blood plasma and in biological membranes of plants and bacteria.
Function. Lyso-phosphatidyl-ethanolamines are involved in cellular processes such as differentiation and migration of certain neuronal cells, but also of various cancer cells. In plants, LPEs function as inhibitors for a key enzyme in membrane lipid degradation, thus retarding senescence of leaves, flowers, and fruits. They are used commercially to stimulate ripening and extend shelf-life of fruit, and increase vase life of cut flowers. Further, LPE lipids serve as precursors for phosphatidyl-ethanolamines.
Breast Cancer & Lipid Metabolism
Breast cancer phospholipid metabolism is a powerful target for new therapies, especially against triple-negative breast cancer.
LPE lipidomics analysis with
|Structural details||species level|
|Variants identified||> 50|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, CL, PC O-, PE O-, LPC O-, LPE O-, Cer, HexCer
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, PC O-, PE O-, Chol, CE, Cer, SM
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!