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Lyso-phosphatidate

We provide MS-based lipid analysis of LPA phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of LPA

Structure. Lyso-phosphatidates (lyso-phosphatidic acids, LysoPtdOH, LysoPA, or LPA) are a type of glycerophosphates, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphate group. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Lyso-phosphatidates influence many biochemical processes in cells and act as lipid mediators with growth factor-like activities. They act upon nearly all cell types, often as signal for proliferation, cytoskeleton re-arrangement, cell differentiation, cytokine secretion, and many other vital cellular processes. Further, there is evidence for the role of LPA lipids in the remodeling of lipid metabolism in cancer. They are a target of pharmaceutical research in the search for new cancer drugs.

Related research

Breast Cancer & Lipid Metabolism
Breast cancer phospholipid metabolism is a powerful target for new therapies, especially against triple-negative breast cancer.
Read more

GENERAL STRUCTURE
LPA

General molecular structure of lyso-phosphatidate.

LPA lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer

REPORTED AS
LPA 18:0;0

An example for the molecular structure of lyso-phosphatidate, specifically LPA 18:0;0.

GENERAL STRUCTURE
LPA

General molecular structure of lyso-phosphatidate.

REPORTED AS
LPA 22:6;0

An example for the molecular structure of lyso-phosphatidate, specifically LPA 22:6;0.

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