About the structure and biological function of LPA
Structure. Lyso-phosphatidates (lyso-phosphatidic acids, LysoPtdOH, LysoPA, or LPA) are a type of glycerophosphates, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphate group. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPA lipids are mainly found in animal blood plasma, though at low concentrations. On a subcellular level, they are enriched in the extracellular space.
Function. Lyso-phosphatidates influence many biochemical processes in cells and act as lipid mediators with growth factor-like activities. They act upon nearly all cell types, often as signal for proliferation, cytoskeleton re-arrangement, cell differentiation, cytokine secretion, and many other vital cellular processes. Further, there is evidence for the role of LPA lipids in the remodeling of lipid metabolism in cancer. They are a target of pharmaceutical research in the search for new cancer drugs.
Related research
Breast Cancer & Lipid Metabolism
Breast cancer phospholipid metabolism is a powerful target for new therapies, especially against triple-negative breast cancer. Read more
GENERAL STRUCTURE LPA
LPA lipidomics analysis with Lipotype
Structural details
species level
Variants identified
> 50
Method
mass spectrometry
Device
Q Exactive Orbitrap (280.000 Res)
Quantification
yes
Delivery time
2-6 weeks
Lipidomics data
pmol & mol%
Figures
included
1Cells Extended includes: LPA, LPC, LPE, LPG, LPI, LPS, CL, PC O-, PE O-, LPC O-, LPE O-, Cer, HexCer
