Home   Lipidomics Analysis   GT3 Analysis 

GT3 Ganglioside

We provide MS-based lipid analysis of GT3 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GT3

Structure. GT3 ganglioside lipids (GT3) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a tri-sialic oligosaccharide unit made of five sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the function of GT3 gangliosides in vertebrates but they are elevated in the human retina where they are suggested to play a specific role in the structure and function of the tissue. They also serve as precursors of more complex gangliosides. Modified GT3 gangliosides have been associated with tumors, representing an attractive target for immunotherapeutic approaches using GT3 ganglioside antibodies. Further, GT3 levels are reduced in Alzheimer disease models.

GENERAL STRUCTURE
GT3

General molecular structure of the ganglioside GT3.

GT3 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GT3 36:1;2

An example for the molecular structure of ganglioside GT3, specifically GT3 36:1;2.

GENERAL STRUCTURE
GT3

General molecular structure of the ganglioside GT3.

REPORTED AS
GT3 42:1;2

An example for the molecular structure of ganglioside GT3, specifically GT3 42:1;2.

About Lipotype

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!