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GM4 Ganglioside

We provide MS-based lipid analysis of GM4 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GM4

Structure. GM4 ganglioside lipids (GM4) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a mono-sialic disaccharide unit. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the function of GM4 gangliosides in vertebrates but they have been found to be a major ganglioside within myelin, the insulating layer that is produced by oligodendrocytes and forms around the axons of neurons. GM4 lipids are increased in the frontal cortex of Alzheimer’s patients. Further, GM4 supports oligodendrocyte proliferation, a process that is important for remyelination of demyelinated neurons and is impaired in multiple sclerosis.

GENERAL STRUCTURE
GM4

General molecular structure of the ganglioside GM4.

GM4 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified < 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GM4 36:1;2

An example for the molecular structure of ganglioside GM4, specifically GM4 36:1;2.

GENERAL STRUCTURE
GM4

General molecular structure of the ganglioside GM4.

REPORTED AS
GM4 42:1;2

An example for the molecular structure of ganglioside GM4, specifically GM4 42:1;2.

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