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GM2 Ganglioside

We provide MS-based lipid analysis of GM2 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of GM2

Structure. GM2 ganglioside lipids (GM2) are a type of gangliosides, a subclass of glycosphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of four sugar molecules. One of them is a sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GM2 gangliosides are components of the cell membrane and may suppress malignant properties of various cancers. The mechanism is suggested to be due to complex formation at the cell surface with membrane proteins. Genetic defects leading to accumulation of GM2, due to increased lysosomal storage  cause Tay-Sachs, Sandhoff and AB variant disease. Further, GM2 lipids bind to a toxin secreted by Clostridium perfringens.

GENERAL STRUCTURE
GM2

General molecular structure of the ganglioside GM2.

GM2 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
GM2 38:1;2

An example for the molecular structure of ganglioside GM2, specifically GM2 38:1;2.

GENERAL STRUCTURE
GM2

General molecular structure of the ganglioside GM2.

REPORTED AS
GM2 40:1;2

An example for the molecular structure of ganglioside GM2, specifically GM2 40:1;2.

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