About the structure and biological function of Gb3
Structure. Gb3 globoside lipids (globo-triaosylceramides, ceramide trihexosides, antigen CD77, or Gb3) are a type of globosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a neutral oligosaccharide unit made of three sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Gb3 globosides are found in vertebrate cells. On a subcellular level, they are enriched in the cell membrane and in lipid rafts.
Function. Gb3 globosides specifically interact with the cellular “death receptor” FasR. When paired to a Gb3, FasR transduces a cell death signal derived from activation of the caspase-8 cascade. A genetic defect in the enzyme alpha-galactosidase leads to accumulation of Gb3, causing Fabry’s disease, a lysosomal storage disease. Further, Gb3 are a component of the cell membrane where they bind to Shigatoxins facilitating their entry into cells.
Gb3 lipidomics analysis with
|Structural details||species level|
|Variants identified||> 10|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf
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