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Gb3 Globoside

We provide MS-based lipid analysis of Gb3 globosides in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of Gb3

Structure. Gb3 globoside lipids (globo-triaosylceramides, ceramide trihexosides, antigen CD77, or Gb3) are a type of globosides, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a neutral oligosaccharide unit made of three sugar molecules. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Gb3 globosides specifically interact with the cellular “death receptor” FasR. When paired to a Gb3, FasR transduces a cell death signal derived from activation of the caspase-8 cascade. A genetic defect in the enzyme alpha-galactosidase leads to accumulation of Gb3, causing Fabry’s disease, a lysosomal storage disease. Further, Gb3 are a component of the cell membrane where they bind to Shigatoxins facilitating their entry into cells.

GENERAL STRUCTURE
Gb3

General molecular structure of the globoside Gb3.

Gb3 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
Gb3 32:1;2

An example for the molecular structure of globoside Gb3, specifically Gb3 32:1;2.

GENERAL STRUCTURE
Gb3

General molecular structure of the globoside Gb3.

REPORTED AS
Gb3 36:1;2

An example for the molecular structure of globoside Gb3, specifically Gb3 36:1;2.

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