About the structure and biological function of LPC O-
Structure. Ether-linked lyso-phosphatidyl-cholines (lysoPAF, or LPC O-) are a type of glycerophosphocholines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid via an ether bond and a phosphocholine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPC O- lipids are found in animals and microbes. On a subcellular level, they may be enriched in the cell membrane and lipid droplets.
Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-cholines. They are precursors to ether-linked phosphatidylcholines and to platelet activating factor (PAF), which is important for inflammatory reactions but also structure and function of the central nervous system. Elevated levels of LPC O- lipids have been found in patients with Alzheimer’s disease.
LPC O- lipidomics analysis with
|Structural details||species level|
|Variants identified||> 25|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer
2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer
LPC O- 15:0;0
LPC O- 20:0;0
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