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Alpha-hydroxy-phyto-sphingosine

We provide MS-based lipid analysis of AP skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of AP

Structure. Alpha-hydroxy-fatty acid [A] phytosphingosine [P] ceramides (CER[AP], or AP) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The function of alpha-hydroxy-phytosphingosines mainly revolves around skin health where they serve structural and signaling roles. AP ceramides contribute to epidermal barrier function which protects against environmental factors and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide profile aberrations can lead or contribute to skin conditions. Further, AP ceramides are increased during winter months in healthy skin and decreased in Albino African skin.

Related research

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Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
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GENERAL STRUCTURE
AP

General molecular structure of alpha-hydroxy-phytosphingosines.

AP lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 100
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

REPORTED AS
AP 20:0;3/26:0;1

An example for the molecular structure of alpha-hydroxy-phytosphingosines, specifically AP 20:0;3/26:0;1.

GENERAL STRUCTURE
AP

General molecular structure of alpha-hydroxy-phytosphingosines.

REPORTED AS
AP 18:0;3/16:0;1

An example for the molecular structure of alpha-hydroxy-phytosphingosines, specifically AP 18:0;3/16:0;1.

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