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Alpha-hydroxy-phyto-sphingosine
We provide MS-based lipid analysis of AP skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.
Details
About the structure and biological function of AP
Structure. Alpha-hydroxy-fatty acid [A] phytosphingosine [P] ceramides (CER[AP], or AP) are a subclass of ceramides. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
AP lipids are found in skin. On a subcellular level, they are enriched in the extracellular lipid matrix of the stratum corneum .
Function. The function of alpha-hydroxy-phytosphingosines mainly revolves around skin health where they serve structural and signaling roles. AP ceramides contribute to epidermal barrier function which protects against environmental factors and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide profile aberrations can lead or contribute to skin conditions. Further, AP ceramides are increased during winter months in healthy skin and decreased in Albino African skin.
GENERAL STRUCTUREAP
AP lipidomics analysis with
Structural details subspecies level Variants identified > 100 Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 3-6 weeks Lipidomics data pmol & mol% Figures included
1 Skin includes:
REPORTED ASAP 20:0;3/26:0;1
GENERAL STRUCTUREAP
REPORTED ASAP 18:0;3/16:0;1
About Lipotype
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
