Home   Lipidomics Analysis   AP Analysis 

Alpha-hydroxy-phyto-sphingosine

We provide MS-based lipid analysis of AP skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.
Request analysis

Details

About the structure and biological function of AP

Structure. Alpha-hydroxy-phyto-sphingosines (CER[AP], or AP) are a type of sphinganines, a subclass of ceramides. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The function of alpha-hydroxy-phytosphingosines mainly revolves around skin health where they serve structural and signaling roles. AP ceramides contribute to epidermal barrier function which protects against environmental factors and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide profile aberrations can lead or contribute to skin conditions. Further, AP ceramides are increased during winter months in healthy skin and decreased in Albino African skin.

Related research

Moisturizer Research
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
Read more

GENERAL STRUCTURE
AP

General molecular structure of alpha-hydroxy-phytosphingosines.

AP lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 100
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

All lipid classes

TAG DAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS Cer CL Chol CE PC O- PE O- LPC O- LPE O- SM HexCer DiHexCer Gb3 Gb4 GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Sulf Erg EE CDP-DAG IPC MIPC M(IP)2C NdS NS NP NH AdS AS AP AH EOdS EOS EOP EOH

REPORTED AS
AP 20:0;3/26:0;1

An example for the molecular structure of alpha-hydroxy-phytosphingosines, specifically AP 20:0;3/26:0;1.

GENERAL STRUCTURE
AP

General molecular structure of alpha-hydroxy-phytosphingosines.

REPORTED AS
AP 18:0;3/16:0;1

An example for the molecular structure of alpha-hydroxy-phytosphingosines, specifically AP 18:0;3/16:0;1.

About Lipotype

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!

*