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Mannosyl-di-(inositol­phosphoryl)-ceramide

Mannosyl-di-(inositol­phosphoryl)-ceramide

We provide MS-based lipid analysis of M(IP)2C phosphosphingolipids in yeast samples and deliver results in as little as two weeks.

About the structure and biological function of Mannosyl-di-(inositol­phosphoryl)-ceramide

About the structure and biological function of M(IP)2C

Structure. Mannosyl-di-(inositol-phosphoryl)-ceramides (mannose-(inositol-P)2-ceramides, or M(IP)2C) belong to the group of phosphosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone bound to two linked phosphorylinositol molecules of which one is mannosylated. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the biological function of mannosyl-di-(inositolphosphoryl)-ceramides but they are important components of biological membranes of fungi. Together with MIPC, they constitute the major sphingolipids in yeasts. As M(IP)2C lipids are not produced in mammals, targeting their synthesis is a strategy for novel antifungal drugs. Further, M(IP)2C ceramides interact with plant defensins, small peptides produced by plants that possess antifungal activity.

Mannosyl-di-(inositol­phosphoryl)-ceramide lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-4 weeks
Lipidomics data
Figuresincluded

STRUCTURE
Mannosyl-di-(inositol­phosphoryl)-ceramide

Mannosyl-di-(inositol­phosphoryl)-ceramide

ABOUT LIPOTYPE

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Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

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example_structure_of_mannosyl-inositolphosphoryl-ceramide_46-0-3.png

Mannosyl-inositol­phosphoryl-ceramide

Mannosyl-inositol­phosphoryl-ceramide

We provide MS-based lipid analysis of MIPC phosphosphingolipids in yeast samples and deliver results in as little as two weeks.

About the structure and biological function of Mannosyl-inositol­phosphoryl-ceramide

About the structure and biological function of MIPC

Structure. Mannosyl-inositolphosphoryl-ceramides (mannose-inositol-P-ceramides, or MIPC) belong to the group of phosphosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone bound to a mannosylated phosphorylinositol molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Mannosyl-inositolphosphoryl-ceramides are important components of biological membranes of fungi. Together with M(IP)2C, they constitute the major sphingolipids in yeasts, where they have multiple functions related to maintenance of cell morphology and are required for the localization of cell membrane proteins. Depending on the immune status of the host, MIPC ceramides of the pathogenic yeast candida albicans indirectly cause immune system disorder and persistent fungal disease.

Mannosyl-inositol­phosphoryl-ceramide lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-4 weeks
Lipidomics data
Figuresincluded

STRUCTURE
Mannosyl-inositol­phosphoryl-ceramide

Mannosyl-inositol­phosphoryl-ceramide

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

read more ➔

example_structure_for_inositolphosphoryl-ceramide_46-0-4.png

Inositol­phosphoryl-ceramide

Inositol­phosphoryl-ceramide

We provide MS-based lipid analysis of IPC phosphosphingolipids in yeast samples and deliver results in as little as two weeks.

About the structure and biological function of Inositol­phosphoryl-ceramide

About the structure and biological function of IPC

Structure. Inositolphosphoryl-ceramides (inositol-P-ceramides, or IPC) belong to the group of phosphosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylinositol molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Inositolphosphoryl-ceramides are substantial components of biological membranes in yeast. In lipid rafts of the cell membrane, IPC lipids interact with membrane proteins with signaling functions – a role similar to those of sphingomyelins in animals. IPC ceramides are also the precursor for further complex glycophosphosphingolipids. Further, the biosynthesis of IPC lipids reduces the pool of intracellular ceramide and thus inhibits programmed cell death.

Inositol­phosphoryl-ceramide lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-4 weeks
Lipidomics data
Figuresincluded

STRUCTURE
Inositol­phosphoryl-ceramide

Inositol­phosphoryl-ceramide

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

read more ➔

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Sphingomyelin

Sphingomyelin

We provide MS-based lipid analysis of SM sphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Sphingomyelin
Lipid Class

About the structure and biological function of Sphingomyelin

About the structure and biological function of SM

Structure. Sphingomyelins (CerPCho, or SM) belong to the group of phosphosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylcholine molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Sphingomyelins play a key role in the cell membrane of animals. They are vital to the formation of lipid rafts and required for the activity of raft-dependent membrane proteins such as some ion channels. They also serve as precursors for sphingolipids in the ‘sphingomyelin cycle’. Further, sphingomyelin metabolism aberrations have been linked to Alzheimer’s and cardiovascular disease.

Sphingomyelin lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-6 weeks
Lipidomics data
Figuresincluded

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

read more ➔