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Gb4 Globoside

Gb4 Globoside

We provide MS-based lipid analysis of Gb4 globosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Globosides
Lipid Group
Gb4 Globoside
Lipid Class

About the structure and biological function of Gb4 Globoside

About the structure and biological function of Gb4

Structure. Gb4 globoside lipids (globo-tetraosylceramides, or cytolipin R) belong to the group of globosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral oligosaccharide unit made of four sugar molecules. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Gb4 globosides are the main glycolipids found in the cell membrane of human erythrocytes. There, they are important for cellular interactions including blood-type determinants, factors which determine the suitability of donor blood for a patient. Each of the three distinct blood group antigens (A, B, and 0) is defined by a variation of the oligosaccharide unit. Gb4 lipids also act as the receptor for the parvovirus B19, which infects rapidly dividing cells of the intestines and the bone marrow causing (fifth disease) in children.

Gb4 Globoside lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-4 weeks
Lipidomics data
Figuresincluded

STRUCTURE
Gb4 Globoside

Gb4 Globoside

ABOUT LIPOTYPE

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Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

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Gb3 Globoside

Gb3 Globoside

We provide MS-based lipid analysis of Gb3 globosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Globosides
Lipid Group
Gb3 Globoside
Lipid Class

About the structure and biological function of Gb3 Globoside

About the structure and biological function of Gb3

Structure. Gb3 globoside lipids (globo-triaosylceramides, ceramide trihexosides, or antigen CD77) belong to the group of globosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral oligosaccharide unit made of three sugar molecules. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Gb3 globosides specifically interact with the cellular “death receptor” FasR. When paired to a Gb3, FasR transduces a cell death signal derived from activation of the caspase-8 cascade. A genetic defect in the enzyme alpha-galactosidase leads to accumulation of Gb3, causing Fabry’s disease, a lysosomal storage disease. Further, Gb3 are a component of the cell membrane where they bind to Shigatoxins facilitating their entry into cells.

Gb3 Globoside lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-4 weeks
Lipidomics data
Figuresincluded

STRUCTURE
Gb3 Globoside

Gb3 Globoside

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

read more ➔

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Dihexosyl­ceramide

Dihexosyl­ceramide

We provide MS-based lipid analysis of DiHexCer glycosphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category

About the structure and biological function of Dihexosyl­ceramide

About the structure and biological function of DiHexCer

Structure. Dihexosylceramides (CerG2, or DiHexCer) belong to the group of diglycosylceramides within the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral disaccharide molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Many dihexosylceramides are key intermediates in the biosynthesis of glycosphingolipids containing three or more sugar molecules such as globosides and gangliosides. Yet, they are vital to cell function and particularly important to lipid raft formation in cells of the innate immune system. They bind to pathogens, mediating immune and inflammatory responses. Further, dihexosylceramide metabolism aberrations are linked to cancers, cardiovascular disease, inflammation, and multiple sclerosis.

Dihexosyl­ceramide lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-4 weeks
Lipidomics data
Figuresincluded

STRUCTURE
Dihexosyl­ceramide

Dihexosyl­ceramide

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

read more ➔

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Hexosylceramide

Hexosylceramide

We provide MS-based lipid analysis of HexCer glycosphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Cerebrosides
Lipid Group
Hexosylceramide
Lipid Class

About the structure and biological function of Hexosylceramide

About the structure and biological function of HexCer

Structure: Hexosylceramides (mono-hexosylceramides, monoglycosylceramides, or HexCer) belong to the group of cerebrosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral sugar molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function: Many hexosylceramides serve as key precursors for the biosynthesis of dihexosylceramides and thus for more complex glycosphingolipids such as globosides and gangliosides. Yet, they are vital to cell function, for example as structural components of cell membranes and lipid rafts. Hexosylceramides are critical to structure, function, and long-term stability of myelin, as well as for axonal growth of neurons. Further, some hexosylceramides are essential for preventing trans-epidermal water loss.

Hexosylceramide lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-6 weeks
Lipidomics data
Figuresincluded

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

read more ➔

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Sulfatide

Sulfatide

We provide MS-based lipid analysis of Sulfatide in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Sulfatide
Lipid Class

About the structure and biological function of Sulfatide

About the structure and biological function of Sulfatide

Structure. Sulfatides (sulfated galactosyl-ceramides, sulfogalactosylceramides, galactosylceramide-sulfates, SO3-GalCer, or Sulf) belong to the group of sulfoglycosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone linked to a sulfated galactose sugar molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Sulfatides are a main constituent of myelin, the lipid coating around neuronal axons. Changes in brain sulfatide levels are linked to Alzheimer’s and Parkinson’s, and an abnormal sulfatide metabolism has been linked to cancers and autoimmune diseases. They also participate in many cellular processes from protein trafficking to signaling. Further, sulfatides are involved in the regulation of glucose uptake. Antibodies to sulfatides are often present in blood serum before the onset of diabetes.

Sulfatide lipidomics analysis with Lipotype

Covered classes0
Approachuntargeted
Method
DeviceQ Exactive Orbitrap (280.000 Res)
Quantification
Delivery time2-4 weeks
Lipidomics data
Figuresincluded

STRUCTURE
Sulfatide

Sulfatide

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!

read more ➔