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Ether-linked lyso-phosphatidyl-ethanolamine

About the structure and biological function of LPE O-

Structure. Ether-linked lyso-phosphatidyl-ethanolamines (LPE O-) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty alcohol via an ether bond and a phosphoethanolamine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-ethanolamines, but they are precursors to ether-linked phosphatidyl-ethanolamines. In the pigmented layer of the human retina that nourishes retinal visual cells, LPE O- lipids are linked to the formation of bisretinoids. Bisretinoids are a family of fluorescent molecules that form in photoreceptor cells and contribute to some retinal diseases, thus LPE O- lipids are suggested to play a role in retinal health.

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Ether-linked lyso-phosphatidyl-choline

About the structure and biological function of LPC O-

Structure. Ether-linked lyso-phosphatidyl-cholines (lysoPAF, or LPC O-) are a type of glycerophosphocholines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty alcohol via an ether bond and a phosphocholine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-cholines. They are precursors to ether-linked phosphatidylcholines and to platelet activating factor (PAF), which is important for inflammatory reactions but also structure and function of the central nervous system. Elevated levels of LPC O- lipids have been found in patients with Alzheimer’s disease.

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Ether-linked phosphatidyl-ethanolamine

About the structure and biological function of PE O-

Structure. Ether-linked phosphatidyl-ethanolamine (plasmanyl-phosphatidyl-ethanolamines, alkyl-phosphatidyl-ethanolamines, or PE O-) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid, a fatty alcohol and a phosphoethanolamine molecule. One of the fatty acids is bound to the glycerol backbone via an ether bond. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Ether-linked phosphatidyl-ethanolamines contain high amounts of arachidonic acid required for the biosynthesis of eicosanoids, bioactive lipids with a great role in inflammation. Levels of PE O- lipids are reduced in the blood of patients with multiple sclerosis. That said, elevated levels have been found in cancers, especially in aggressive forms. Further, PE O- lipids are important membrane constituents of neutrophils, the most abundant type of white blood cells in humans.

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Ether-linked phosphatidyl-choline

About the structure and biological function of PC O-

Structure. Ether-linked phosphatidyl-cholines (plasmanyl-phosphatidylcholines, alkyl-phosphatidylcholines, Platelet Activating Factor, PAF, or PC O-) are a type of glycerophosphocholines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid, a fatty alcohol and a phosphocholine molecule. One of the fatty acids is bound to the glycerol backbone via an ether bond. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Ether-linked phosphatidyl-cholines contain high amounts of arachidonic acid required for the biosynthesis of eicosanoids, bioactive lipids with a great role in inflammation. Levels of PC O- lipids are reduced in the blood of patients with multiple sclerosis. On the other hand, elevated levels have been found in cancers, especially in aggressive forms. Further, PC O- lipids are important membrane constituents of neutrophils, the most abundant type of white blood cells in humans.

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