COVID-19: RESEARCH CONTINUES
We have taken appropriate measures to ensure the safety of everyone at Lipotype and her/his family. Nearly all of us are working from home. The analytical team keeps the machines running in order to ensure business works normally.
We continue to receive samples, analyze them and send out the data as usual. We compiled the following Q&A summarizing the status quo:
We are following the development of this pandemic and adjust our analytical operations as necessary to ensure that you receive your lipidomics data. Any changes that will affect your project will be immediately communicated to you.
Yes, our team is available as usual to support your research project.
Yes, we continue receiving samples.
Yes. According to German regulations, with its Biosafety Level 2 (BSL 2) laboratories Lipotype is allowed to conduct analytical testing of samples related to SARS-CoV-2. We will support research projects which aim to overcome this pandemic with a reduced turnover time. We offer a “turbo delivery option” which is reducing the standard delivery time (for most projects 6 weeks) by 50%. This option is offered for free.
Please send your samples according to the timeline discussed with us.
We continue receiving samples from customers worldwide. Please consult your preferred courier provider or visit their website for shipment updates.
We recommend sending your samples by World Courier. Please find the global contacts here.
No, our lipidomics analyses run as usual.
Yes, we continue to deliver your lipidomics data in time. There can be changes from one day to another which can delay delivery times of the results. We will immediately contact you if future developments affect your lipidomics data delivery date.
Please notify us immediately. We will contact the German health department to coordinate our actions.
LIPIDS IN COVID-19
The COVID-19 virus is an enveloped coronavirus that receives its lipid membrane by budding into the ERGIC. The ERGIC is a cellular compartment that is involved in the transport of newly synthesized proteins from the endoplasmic reticulum to the Golgi complex within the cell – including the COVID-19 virus proteins produced by the infected cell.
The membrane proteins of the virus determine that the virus’ nucleocapsid, the protein shell enclosing its genetic material, binds to the cytosolic side of the ERGIC membrane. Then the virus receives its membrane by being enveloped by the ERGIC membrane segment that had been modified to contain the newly synthesized coronavirus proteins.
The interplay between lipids in the ERGIC membrane and the COVID-19 membrane proteins thus plays an essential role in viral assembly. This aspect of virology has received little attention until now. Lipidomics provides an unexplored tool to discover this virgin land and its completely novel aspects of virus infection.
We are offering our expertise to support researchers who are interested in lipid changes during viral infection and envisage the following projects:
Determining the lipid composition of purified COVID-19, SARS, and MERS viral-like particles or of the purified virus particles.
Host cell lipid metabolism
Following the changes in host cell lipid metabolism infected with different coronaviruses by lipidomics.
Exploring the changes during COVID-19 infection and follow how patients are reacting during the progression of the disease to determine lipid metabolism changes associated to different disease states.
Differentiating between patients that have shown (I) no symptoms, (II) mild symptoms, (III) severe symptoms and had to be hospitalized, and (IV) life threatening symptoms and had to be supported by a ventilator for improved patient stratification.
Elaborating lipidomics as a companion diagnostic in testing the efficacy of potential drugs against COVID-19 infection and in vaccine trials.