Henri Deda

Posts by henri.deda

A good month for public access to research

July has been a great month. Three new publications with Lipotype Shotgun Lipidomics technology have been put out, and the Lipidomics Resource Center received its first major update. Read more about this!

One month – three publications

This month, three new publications with Lipotype Shotgun Lipidomics technology were published!

Paper 1: Parkinson’s disease
In Parkinson’s, excessive contacts between mitochondria and endoplasmic reticulum lead to abnormal lipid trafficking. This stops the release of “sleep” peptides affecting sleep patterns of patients long before they experience motor dysfunctions

Paper 2: vacciness
Adjuvants like the well-established AS03 are agents in vaccines that do not provide immunity but stimulate the immune system. However, the molecular mechanism behind AS03’s adjuvant effect had yet to be fully illuminated. These new results could be applied to design novel vaccine adjuvants

Paper 3: cancer therapeutics
Oncogenic RAS proteins must localize to the plasma membrane to act. The recently described oxanthroquinone G01 disrupts that, affects levels of some lipids and synergizes with other compounds that affect oncogenic RAS proteins. G01 could become a new anti-RAS therapeutic

As always: access the Lipidomics Resource Center to study more publications!

The first major Lipidomics Resource Center update

We strive for scientific excellence, and therefore must hold on to the fact that all science is just as good as the research which precedes it. Therefore, we created the Lipidomics Resource Center which provides access to lipidomics publications and whitepapers to empower your research. However, that is just not enough. Therefore we added a completely new category: “products”!

There is a whole universe of research which you cannot access through reading scientific publications. And that is most of industry research. However, this type of research is reflected by product development and patents. The new category “products” gives you access to exactly this kind of hidden information.

Lipidomics is no longer a thing of the lab. It is out in the world. Now, you can learn about it!

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Parkinson’s Disease, Fruit Flies and Lipotype

What happened

Do fruit flies suffer from Parkinson’s? Not exactly. But patients who suffer from this neurological disease experience disturbed sleep patterns long before motor dysfunctions. This can be modelled in fruit flies. Researchers from the Netherlands and Germany showed that excessive contacts between mitochondria and endoplasmic reticulum in Parkinson’s flies lead to abnormal lipid trafficking. This prevents the release of “sleep” neuropeptides, which affects sleep patterns.

Lipotype performed lipid analysis on fruit fly heads and various organelles. The results clearly supported the researchers’ hypothesis: in Parkinson’s fruit flies the lipid PtdSer is transferred from the endoplasmic reticulum to the mitochondria, and converted to PtdEtn at a higher rate, when compared with healthy flies. This was proven through Lipotype Shotgun Lipidomics technology.

Read the full publication

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease – Neuron, 2018
Jorge S Valadas, Giovanni Esposito, Dirk Vandekerkhove, Katarzyna Miskiewicz, Liesbeth Deaulmerie, Susanna Raitano, Philip Seibler, Christine Klein, Patrik Verstreken

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Job Perspective: Lipotype Lab Assistant

Dresden, Germany | Full/Part-time | Begin: preferably today

Are you interested in a position with competitive pay in a friendly atmosphere with career perspectives?

Is that you?

We are looking for a lab assistant who will be involved with lipid analysis and is willing to become an expert in mass spectrometry. You should be an organized person with experience in laboratory work who gets a kick out of performing reproducibly and precisely.

Lipotype – Lipidomics for a better life

Lipotype is a spin off company of the MPI of Molecular Cell Biology and Genetics in Dresden, founded by no other but Kai Simons. We are serving pharma, cosmetics and nutrition companies as well as academia worldwide. Most excitingly, we are engaged in R&D aiming at increasing global health. You can be part of a team that is moving health and prevention into unexplored territory. Join the lipid revolution!

A fantastic workplace atmosphere

Down-to-earth, driven, enthusiastic – just a few of the attributes visitors use to describe us. Our offices are cheerful with plants and other accents of green, and “strategically placed” exercise balls encourage communication. All of us contribute to Lipotype.

Apply now

Please send your application to career@lipotype.com. If you have further questions, please contact Evi Kluge (kluge@lipotype.com). You can open and read the  PDF Document  here.

Join our Lipotype team to realize our joint vision of lipidomics for a better life!

Or at least follow us on  LinkedIn,  Twitter,  Facebook or  Google+, and  subscribe to our newsletter to stay updated on lipids and lipidomics!

lipid analysis for skin penetration properties of saturated phospholipids

Lipotype put online a new skin lipidomics customer reference with Lipoid about lipid analysis for skin penetration properties of saturated phospholipids.

What is skin lipidomics

The physiology of skin derives from its structure and composition of its topmost layer, where cells are glued together by lipids. Their composition is influenced by natural conditions, such as age and gender, but also various diseases. Lipotype Skin Shotgun Lipidomics Technology provides the tools to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and personalized cosmetics.

The project in short

Lipoid conducted this novel study to investigate skin penetration properties of dermal formulations based on hydrogenated phospholipids. Common to all topically used phospholipids is their ability to interact with skin structures and the similarity to epidermal lipids. For the first time, the quantitative analysis of both exogenous phospholipids and endogenous skin lipids within a single measurement was demonstrated. The results confirm the properties of hydrogenated phospholipids to penetrate and accumulate in upper epidermal layers. Lipotype performed lipid analysis of phospholipids of an applied formulation, especially focusing on phosphatidylcholine.

About Lipoid

Phospholipids are widespread functional ingredients, not only in pharmaceutical formulations, but in cosmetic and dietetic products as well. Lipoid was the first to offer a wide variety of phospholipids for use in the production of drug products. Today, the majority of approved drugs containing phospholipids are prepared using raw materials from Lipoid. Based on these findings, Lipoid will conduct further investigations to improve delivery and fixation of an active pharmaceutical ingredient.

Find the full customer reference

Customer reference Lipoid: lipid analysis for skin penetration properties of saturated phospholipids

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New Job Offer: We are Hiring a Technical Assistant

Lipotype is an innovative lipidomics provider located in Dresden. We are looking for a Technical Assistant to support our start-up team. You will be responsible for sample processing for lipid analysis with mass spectrometers. Tasks include automated or manual sample preparation, lipid extraction using a robotic liquid handling station, organization of sample sets, laboratory maintenance including preparing chemicals and monitoring consumables, and associated laboratory routines.

Who you are

You are a highly organized person, accustomed to routine analytical tasks requiring high reproducibility, precision and cleanliness. Fluency in English is a prerequisite skill. Hands-on experience in automated liquid handling and high-throughput processes, as well as a practical knowledge of GLP and QM is an asset. You are trained as biological technical assistant/ medical technical assistant (biologisch-techn. / medizinisch-techn. Assistentin – BTA / MTA) or within an equivalent training program in biology, biotechnology or medicine.

Who we are

Lipotype delivers comprehensive, absolutely quantitative lipid analysis services for clinical and biological samples on a high-throughput scale. Drawing on many years of cutting edge research experience, Lipotype offers high quality lipid analysis services for a wide range of customers and applications including biomarker identification for clinical researchers, pharma and biotech companies, functional food development for the food industry, claim support for the cosmetics industry, as well as for the small-scale profiling needs of academic researchers.

Lipotype is a spin-off company from the Kai Simons and Andrej Shevchenko labs of the world-renowned Max-Planck-Institute of Molecular Cell Biology and Genetics in Dresden, Germany.

Apply now

Please send your application to career@lipotype.com. If you have further questions, please contact Evi Kluge (kluge@lipotype.com). You can open and read the  PDF Document  here.

Join the Lipotype team to realize our joint vision of lipidomics for a better life.

Or at least follow us on  LinkedIn,  Twitter,  Facebook or  Google+, and  subscribe to our newsletter to stay updated on lipids and lipidomics!

How lipids change biological research

Lipotype published a German article about lipidomics in the LABO magazine.

About LABO magazine

The German magazine LABO publishes application-oriented and competent articles about products and services for industry and research laboratories. With its writings, it connects people and markets, providing precisely all necessary information for daily work in the area of analytics and lab technology.

The article in short

The article sums up the recent developments and changes in lipids and lipidomics research and provides a brief summary of Lipotype’s services and history. Finally, it focuses on the conclusion that lipids may have a strong impact on the not so far future of medicare and personalized medicine. This opinion piece in the end is accompanied by two examples of current research publications.

Read the full article

Wie Lipide die biologische Forschung verändern – Die Revolution der Fette
Christian Klose, Henri Deda

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Where to meet Lipotype in June?

Dr Oliver Uecke and Dr Christian Klose will attend two conventions in the US in June. Besides that, Lipotype will support two academic events in the USA.

Meet Lipotype at…

18. – 21. June 2018
World Preclinical Congress, Boston, USA
Come and visit us at our booth 212!

The WPC focuses on the latest trends and technologies impacting drug discovery and translational research.

Or attend the Tech Talk of Dr. Christian Klose on the 20th of June at 9:30 am about “Shotgun Lipidomics Technology for High-Throughput Drug Discovery” on track Phenotypic Screening and Chemical Biology. We will also present a poster.


23. – 25. June 2018
We will attend the Scientific Sessions of the ADA. Visit our booth 559!

More than 13.000 visitors attend the Scientific Sessions of the ADA to discover cutting-edge research and technology, ground-breaking studies, and advances in diabetes care.


If you want to schedule an individual meeting   drop us a line!

Lipotype is sponsoring the following Events

06. – 08. June 2018
The 2018 Penn State Summer Symposium in Molecular Biology is entitled Frontiers in Metallobiochemistry and has assembled prominent researchers interested in metallobiochemistry. The symposium provides access to some truly outstanding lectures and presentations.


24. – 29. June 2018
FASEB: Lipid Droplets on the Move from Health to Disease, Colorado, USA
The Federation of American Societies for Experimental advances health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to our societies and their members. This FASEB’s meeting goal is to facilitate the sharing of the most up-to-date research findings and insights and to catalyze the continued growth of lipid droplet studies.

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The new Lipidomics Resource Center

With great research comes great science

We strive for scientific excellence. But all science on earth is just as good, as the research which precedes it. Which is why we have been discussing solutions to provide better access to lipidomics publications – for free, to everybody.

Over the course of the last months, we developed a new platform: the Lipidomics Resource Center. Let us show you how it empowers your research!

What you can do

You can use the Lipidomics Resource Center to search all uploaded publications and their abstracts for authors and journals or anything else. (You can even include all worldwide available lipidomics publications on PubMed.gov!) Or, filter all uploaded publications with our in-depth tag system by dimensions like sample type or research application. Even reading the full abstract without leaving the platform is possible.

There are yet more things you can do with the Lipidomics Resource Center. Just go and play with it. Over time, we will make improvements and add new publications and features. We want you to discover the world of lipidomics research in an unprecedented way – an easy one.

Check out the Lipidomics Resource Center

Visit the Lipidomics Resource Center today and empower your lipidomics research!

Follow us on  LinkedIn,  Twitter,  Facebook or  Google+, and  subscribe to our newsletter to stay updated on lipids and lipidomics!

Lipotype performed lipid analysis of bacteria for future antimicrobial strategies

What happened

Pseudomonas aeruginosa is a multi-drug resistant bacteria, and can cause serious illnesses such as pneumonia or sepsis syndromes. The publication from TU Braunschweig shows that, when grown under unaerobic biofilm conditions, the bacterium produces less of a protein, which binds specifically to the central hub of phospholipid metabolism.

With Lipotype shotgun lipidomics, a diverse response of Pseudomonas aeruginosa at the lipid head group and fatty acid level was demonstrated. This increased the susceptibility to a wide range of antibiotics which is important for the future development of new antimicrobial strategies.

Read the full publication

A phosphatidic acid-binding protein is important for lipid homeostasis and adaptation to anaerobic biofilm conditions in Pseudomonas aeruginosa – Biochemical Journal, 2018
Maike K Gronewald, Marco Massmig, Stefanie Hebecker, Linna Danne, Zofia Magnowska, Manfred Nimtz, Franz Narberhaus, Dieter Jahn, Dirk W Heinz, Lothar Jänsch, Jürgen Moser

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Dr. Christian Klose, head of research and development at Lipotype, will present at XPOMET convention this Thursday.

Starting tomorrow, the XPOMET will take place in Leipzig, Germany. The XPOMET convention focuses on interdiscliplinary and novel approaches to advance healthcare and medicine. It will feature topic-specific think tanks, discussions and the Future Health Exhibition. More than 80 speakers will present to the up to 2000 attendees.
The XPOMET is the first and only event of its kind.

Come and listen!
What – Innovative lipid analysis for industrial and academic applications
When – Thursday, 22nd March at 1:30 pm
Where – StageX Biotech & New Pharma

Download the XPOMET convention program:
XPOMET convention program 2018 (EN)

Can’t attend? Request your copy of the full presentation:
Send us an email and request your full copy of the XPOMET 2018 Lipotype presentation!