Skin penetration of saturated phospholipids

Lipoid conducted this novel study to investigate skin penetration properties of dermal formulations based on hydrogenated phospholipids. Common to all topically used phospholipids is their ability to interact with skin structures and the similarity to epidermal lipids. For the first time, the quantitative analysis of both exogenous phospholipids and endogenous skin lipids within a single measurement was demonstrated. The results confirm the properties of hydrogenated phospholipids to penetrate and accumulate in upper epidermal layers.

Lipotype performed lipid analysis of phospholipids of an applied formulation, especially focusing on phosphatidylcholine. Further investigations will be conducted to improve delivery and fixation of an active pharmaceutical ingredient.

About Lipoid
Lipoid was the first to offer a wide variety of phospholipids for use in the production of drug products. Phospholipids are widespread functional ingredients, not only in pharmaceutical formulations, but in cosmetic and dietetic products as well. For more information see

The effect of saturated phospholipids on human skin assessed with shotgun lipidomic analysis – Phospholipid Research Center, 2018
D Gutekunst, C Klose, C Heidecke, P van Hoogevest (This study was kindly supported by Lipoid GmbH.)