Lipotype performed lipid analysis of bacteria for future antimicrobial strategies

Henri Deda April 16, 2018

What happened

Pseudomonas aeruginosa is a multi-drug resistant bacteria, and can cause serious illnesses such as pneumonia or sepsis syndromes. The publication from TU Braunschweig shows that, when grown under unaerobic biofilm conditions, the bacterium produces less of a protein, which binds specifically to the central hub of phospholipid metabolism.

With Lipotype shotgun lipidomics, a diverse response of Pseudomonas aeruginosa at the lipid head group and fatty acid level was demonstrated. This increased the susceptibility to a wide range of antibiotics which is important for the future development of new antimicrobial strategies.

Read the full publication

A phosphatidic acid-binding protein is important for lipid homeostasis and adaptation to anaerobic biofilm conditions in Pseudomonas aeruginosa – Biochemical Journal, 2018
Maike K Gronewald, Marco Massmig, Stefanie Hebecker, Linna Danne, Zofia Magnowska, Manfred Nimtz, Franz Narberhaus, Dieter Jahn, Dirk W Heinz, Lothar Jänsch, Jürgen Moser

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Publication, Academia

COVID-19, a Malaria Treatment and Lipidomics

Henri Deda July 6, 2020

A famous malaria treatment has been debated as a medical option in preventive measures against COVID-19. Prominent figures continued to market the malaria medicine as a quick breakthrough to combat the pandemic. However, the debate was fierce from the beginning.

Lipidomics uncovers hidden links between lipids

Henri Deda June 8, 2020

Researchers at Oslo University Hospital applied lipidomics when using lipid metabolism inhibitors and discovered an unexpected modulation of lipid metabolism.

When to eat fatty meals: nutrition researchers discover new “biological lipid metabolism clock”

Henri Deda December 11, 2019

Just in time of Christmas, scientists from the German Institute for Human Nutrition (DIfE) and Lipotype GmbH have published their results of their research on the influence of fatty breakfasts and dinners on lipid metabolism. Their newly discovered “biological lipid metabolism clock” fills a gap in nutritional medicine to activate nutrition for prevention and intervention, and to research how specific foods at specific times of the day can contribute to our health or disease.