Skin lipidomics: a tool for understanding skin aging at the molecular level

Lipotype published in SOFW Journal about skin lipidomics to better understand skin aging

The lipid composition of human skin is essential for its function; however the simultaneous quantification of a wide range of skin lipids, belonging to both stratum corneum and sebum, is not trivial. Recently we developed a new, “shotgun” mass spectrometry-based method characterized by a broad coverage of lipids, absolute quantitation, high reproducibility and high-throughput providing comprehensive insight into skin lipid composition [1].

We applied this method in a large-scale study of natural lipid variability of human skin. In this study we analyzed samples from 104 individuals of both sexes of different ages. We discovered gradual changes in the skin lipidome correlated with age but no sex-specific differences. Our novel method enables detailed and broad insights into skin lipidomes, both in terms of lipidome coverage and sample number. Therefore, skin shotgun lipidomics has the potential to become useful in studies related to skin aging and anti-aging product claims support.

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Click her to read the full article in SOFW Journal


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[1] Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry – Scientific Reports, 2017
Tomasz Sadowski, Christian Klose, Mathias J. Gerl, Anna Wójcik-MaciejewiczRonny HerzogKai SimonsAdam Reich, Michal A. Surma

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